Friday's SmackDown was a bad night for The Usos.

In the main event of the episode, Jimmy & Jey Uso lost to the LWO's Rey Mysterio & Santos Escobar. Escobar pinned Jimmy to get the victory with help from Kevin Owens & Sami Zayn.

Owens & Zayn were out for revenge after being attacked by The Usos earlier in the show. The Usos were going for a double splash when Owens made his way out to cause a distraction. That allowed Escobar to take out Jey Uso. With the referee's attention turned away, Zayn pushed Jimmy off the top rope. Mysterio hit a 619 and Escobar followed with a splash to get the win.

Roman Reigns was shown looking upset with The Usos after their loss.

Reigns also berated The Usos earlier in the night for getting involved in a face-to-face segment between Owens & Zayn and Reigns & Solo Sikoa. While Reigns was cutting a promo on Zayn, The Usos launched a sneak attack on the Undisputed WWE Tag Team Champions. Reigns was angry that The Usos ruined his plan. There was then a moment where Reigns accidentally bumped into Sikoa as he was leaving the ring.

Reigns & Sikoa are challenging Owens & Zayn for the Undisputed WWE Tag Team titles at Night of Champions on Saturday, May 27. Before the pay-per-view, there will be a KO Show segment with Reigns & Sikoa on SmackDown next Friday.

More coverage from last night —

WWE SmackDown spoilers from Columbia, South CarolinaWWE Women's Tag Team titles vacated due to Liv Morgan injuryKO Show, US title match set for next week's WWE SmackDownWWE SmackDown live results: Reigns & Sikoa face-to-face with Owens & Zayn

WWE SmackDown video highlights —

Kevin Owens & Sami Zayn go face-to-face with Roman Reigns & Solo Sikoa

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Roman Reigns berates The Usos

Pretty Deadly make their SmackDown in-ring debut against The Brawling Brutes

Zelina Vega vs. Asuka

Bianca Belair makes the save for Zelina Vega

AJ Styles appears on The Grayson Waller Effect

LA Knight turns against Rick Boogs after their loss to The Street Profits

Cameron Grimes is going to the moon

Alba Fyre & Isla Dawn vs. Valentina Feroz & Yulisa Leon

Damage CTRL challenge Raquel Rodriguez to a match next week

Sheamus silences Austin Theory with a Brogue Kick

Paul Heyman tells The Usos that Roman Reigns forgives them

The LWO vs. The Usos

SmackDown fallout: LA Knight says he didn't lose — Rick Boogs did

SmackDown fallout: Alba Fyre & Isla Dawn are ready to dominate SmackDown