Greenburg,Pennsylvania: Multiple people were killed early Sunday in a crash involving a tour bus, two tractor-trailers and passenger vehicles in Pennsylvania, officials said.

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Pennsylvania Turnpike spokesman Carl DeFebo confirmed fatalities on Twitter, but did not provide a number. A “prolonged closure” of the turnpike is likely, DeFebo said.

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The crash happened in Westmoreland County, near Pittsburgh, around mile marker 86. The crash closed the turnpike between New Stanton at Exit 75 and Breezewood at Exit 161, DeFebo tweeted.

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The tour bus flipped on its side, DeFebo told The Tribune-Review. He said National Transportation Safety Board investigators were called to the scene.

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Further details weren’t immediately available.

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