London: Roger Federer and Rafael Nadal were set up for a potential semi-final at Wimbledon in Friday’s draw, while Serena Williams was placed in what shapes up as by far the toughest quarter of the women’s field.

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With defending champion Novak Djokovic in the top half of the men’s bracket, the No. 2-seeded Federer and No. 3-seeded Nadal were placed together in the bottom half. Nadal is ranked No. 2, and Federer No. 3, but that was reversed by Wimbledon’s seeding system, which takes into account grass-court results over the past two years.

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The possible men’s quarter-finals are No. 1 Djokovic against No. 7 Stefanos Tsitsipas, and No. 4 Kevin Anderson, last year’s runner-up, against No. 6 Alexander Zverev on one side of the field, and Federer v No. 8 Kei Nishikori, and Nadal v No. 5 Dominic Thiem on the other. Nadal-Thiem would be a rematch of the 2018 and 2019 French Open finals, both won by Nadal.

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The women’s quarter-finals could be No. 1 Ashleigh Barty v No. 5 Angelique Kerber, the defending champion” No. 3 Karolina Pliskova v No. 8 Elena Svitolina” No. 2 Naomi Osaka v No. 7 Simona Halep” No. 4 Kiki Bertens v No. 6 Petra Kvitova, the two-time champion who must decide whether to play after being sidelined with an injured left forearm.

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Williams, a seven-time champion at the All England Club and owner of 23 Grand Slam titles in all, might face Kerber in the fourth round — a rematch of their 2018 Wimbledon final and 2016 Australian Open final, both won by Kerber — and then French Open champion Barty in the quarter finals.

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That section of the field also includes past Wimbledon champions Garbine Muguruza and Maria Sharapova, and strong grass-court players Julia Goerges, Belinda Bencic, Donna Vekic, Kaia Kanepi and Alison Riske. Kerber could meet Sharapova in the third round.

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At least Williams, who as usual skipped the grass-court tune-up events, gets a chance to work herself into form. She opens against a qualifier, 162nd-ranked Giulia Gatto-Monticone of Italy, then could face another qualifier in the second round.

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The most intriguing first-round matchup in either the men’s or women’s bracket involves the other Williams sister: Venus, 39, will take on 15-year-old American Coco Gauff, the youngest qualifier at the All England Club in the half-century Open era.

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Nadal starts off against qualifier Yuichi Sugita of Japan, and Federer’s first opponent is Lloyd Harris, a 22-year-old South African making his Wimbledon debut. Djokovic will get things going in Centre Court on Monday against Philipp Kohlschreiber, a former top-20 player who was a 2012 quarter-finalist at Wimbledon and beat Djokovic on a hard court at Indian Wells, California, this year.

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Intriguing first-round pairings include: Thiem against 2017 semi-finalist Sam Querrey; 12th-seeded Fabio Fognini against 21-year-old American Frances Tiafoe; No. 19 seed Felix Auger-Aliassime against Vasek Pospisil in an all-Canadian matchup; and Nick Kyrgios against Jordan Thompson in an all-Australian matchup, with the winner likely facing Nadal, who was upset by Kyrgios in the fourth round at Wimbledon in 2014.